1798年吴瑭著《温病条辨》首创安宫牛黄丸。其后同仁堂开始生产安宫牛黄丸。1870年乐十世乐平泉修订《同仁堂传统配本》，首列瘟疫门，安宫牛黄丸是瘟疫门首药。
Angong Niuhuang Pills were invented by Wu Tang and documented in his work Wenbingtiaobian in 1798, and Tong Ren Tang began to produce Angong Niuhuang Pills thereafter. In 1870, Le Pingquan, the tenth generation of the Le family, firstly included the category of epidemic diseases in his amendment to the Tong Ren Tang Traditional Chinese Medicine Prescription and considered the Angong Niuhuang Pills as the preferred medicine for this category.

同仁堂安宫牛黄丸有文字记载的传承至今149年。在百余年中，同仁堂将自身的制药工艺和清宫御药房制药标准、传统中医药文化和中华文化有机结合，形成了安宫牛黄丸传统制作技艺。
Tong Ren Tang Angong Niuhuang Pills have a documented history of 149 years. Through over a hundred years of development, Tong Ren Tang integrated its owned medicine production techniques with the medicine production standards for the imperial family of Qing Dynasty, traditional Chinese medicine culture and Chinese culture, forming its owned traditional production techniques of Angong Nihuang Pills.